Prenatal Rapamycin Results in Early and Late Behavioral Abnormalities in Wildtype C57Bl/6 Mice
نویسندگان
چکیده
منابع مشابه
Prenatal drug exposure: behavioral functioning in late childhood and adolescence.
The knowledge base on the long-term implications of prenatal drug exposure in human development is extremely limited, but suggests that children with drug-using parents are at high risk for nonoptimal development. The literature, however, provides some evidence that this risk is related to environmental factors. To date, there is no compelling evidence that history of prenatal drug exposure aff...
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Zfhx2 (also known as zfh-5) encodes a transcription factor containing three homeobox domains and 18 Zn-finger motifs. We have reported that Zfhx2 mRNA is expressed mainly in differentiating neurons in the mouse brain and its expression level is negatively regulated by the antisense transcripts of Zfhx2. Although the expression profile of Zfhx2 suggests that ZFHX2 might have a role in a particul...
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BACKGROUND Children are at daily risk for exposure to organophosphate insecticides, of which the most common is chlorpyrifos (CPF). Exposure of pregnant women to CPF was linked to decreased birth weight, abnormal reflexes, reduction in IQ, as well as increased maternal reports of signs of pervasive developmental disorder. The aim of current study was to examine the long term effects of prenatal...
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Female C57BL6 mice were exposed to 0 or 800 ppm carbon disulfide (CS2), 6 h/d, 5 d/wk for 20 weeks. The neurologic function of all mice was assessed once at the end of exposures using a functional observational battery. General health effects included a decrease in body weight gain, piloerection, hunched body posture, and ptosis. Treatment-related effects included altered gait (uncoordinated pl...
متن کاملLate Antiquity and Early Islam
In this paper, an investigation on the relation between state-building and Near Eastern religion is attempted. Analyzing the city-state of Ḥaṭrā (Iraq, close to Kirkuk), it is demonstrated that pre-Islamic state craft in the region was dependent on the initiative of the Parthian monarchy in Iran. The kings of the Arsacid dynasty attempted to bestow the local Arabic tribes in the Jazira with a c...
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ژورنال
عنوان ژورنال: Behavior Genetics
سال: 2012
ISSN: 0001-8244,1573-3297
DOI: 10.1007/s10519-012-9571-9